Imagine layers of tender lasagna noodles, a creamy buffalo ranch cheese mixture, and shredded rotisserie chicken, all baked to bubbly, golden perfection. That’s the satisfying experience of this Cheesy Buffalo Ranch Chicken Lasagna. This recipe takes the beloved comfort of traditional lasagna and infuses it with the tangy heat of buffalo sauce and the cool, creamy goodness of ranch, creating a flavor combination that’s both familiar and exciting. I remember the first time I made this dish. It was for a casual family gathering, and I wanted to prepare something that would please everyone. The combination of buffalo and ranch flavors was a hit, and the ease of using rotisserie chicken made the preparation process a breeze.

Cheesy Buffalo Ranch Chicken Lasagna: A Comforting Twist on a Classic
Layers of lasagna noodles, creamy buffalo ranch cheese, and shredded chicken baked to bubbly perfection. A simple and delicious twist on classic lasagna.
- Prep Time: 20 minutes
- Cook Time: 55 minutes
- Total Time: 1 hour 15 minutes
- Yield: 8–10 servings 1x
- Category: Main Course, Dinner
- Method: Baking
- Cuisine: American
Ingredients
- 12 oz lasagna noodles
- 3 ½ cups shredded rotisserie chicken
- 1 packet ranch seasoning
- 24 oz cream cheese, softened
- 1 cup buffalo sauce
- ½ cup milk
- 2 cups shredded cheddar cheese
- 2 cups shredded mozzarella cheese
- Optional: ranch dressing, green onions, blue cheese crumbles
Instructions
- Prepare the Cheese Mixture: In a large mixing bowl, combine softened cream cheese, ranch seasoning, buffalo sauce, milk, cheddar cheese, and 1 ½ cups of the mozzarella cheese. Mix until smooth and well incorporated. Use a hand mixer or stand mixer for a smoother mixture. Taste the mixture and adjust the seasoning as needed.
- Cook the Lasagna Noodles: Bring a large pot of salted water to a boil. Cook the lasagna noodles according to package instructions until al dente. Drain and lay flat on a clean surface to prevent sticking. If using oven-ready noodles, skip this step.
- Assemble the Lasagna: Spread a thin layer of the cheese mixture on the bottom of a 9×13-inch baking dish. This prevents the noodles from sticking and ensures even cooking. Lay down a layer of lasagna noodles. Spread another layer of the cheese mixture on top of the noodles, followed by a layer of shredded chicken. Repeat the layers, ending with a layer of the cheese mixture on top. Sprinkle the remaining ½ cup of mozzarella cheese evenly over the final layer.
- Bake: Cover the baking dish tightly with aluminum foil and bake in a preheated oven at 375°F (190°C) for 45 minutes. The foil helps to trap moisture and ensures even cooking.
- Uncover and Bake: Remove the foil and bake uncovered for an additional 10 minutes, or until the cheese on top is bubbly and golden. This allows the cheese to brown and the lasagna to set.
- Rest and Serve: Let the lasagna rest for 8–10 minutes before slicing to allow the layers to set. This makes it easier to slice and serve. Garnish with optional toppings such as ranch dressing drizzle, chopped green onions, or blue cheese crumbles.
Notes
- Soften cream cheese fully.
- Cook noodles al dente.
- Layer ingredients evenly.
- Let lasagna rest before slicing.
The dish was a resounding success, and everyone asked for the recipe. This recipe is perfect for beginner cooks. It simplifies the often daunting task of making lasagna by using rotisserie chicken and a pre-made ranch seasoning packet, making it incredibly time-efficient. The simple layering process and clear instructions ensure success even for those new to baking. Plus, the combination of flavors is a guaranteed crowd-pleaser, making it a perfect dish for gatherings, potlucks, or family dinners.
Ingredients and Preparation: Building Layers of Flavor
This recipe relies on a combination of familiar ingredients that, when layered and baked, create a comforting and flavorful lasagna. Here’s a detailed breakdown with added tips and tricks to ensure success:
Lasagna:
- Lasagna Noodles: 12 ounces. Use oven-ready lasagna noodles for an even easier preparation, as they require no pre-boiling. If using traditional lasagna noodles, cook them until al dente to prevent them from becoming mushy during baking. Drain the noodles thoroughly and lay them flat on a clean surface to prevent sticking.
- Rotisserie Chicken, Shredded: 3 ½ cups. Using rotisserie chicken saves significant time and adds a flavorful base to the lasagna. Ensure the chicken is shredded into bite-sized pieces for even distribution throughout the dish. Remove the skin for a leaner option.
Cheese Mixture:
- Ranch Seasoning Packet: 1 packet. This provides the signature ranch flavor that complements the buffalo sauce. You can also use a homemade ranch seasoning blend for a more personalized touch.
- Cream Cheese, Softened: 24 ounces. Softened cream cheese is crucial for a smooth and creamy cheese mixture. Ensure it’s at room temperature for easy mixing. To soften quickly, cut the cream cheese into small cubes and let it sit at room temperature for about 30 minutes.
- Buffalo Sauce: 1 cup. Use your favorite buffalo sauce. Adjust the amount to control the level of spiciness. For a milder flavor, use a mild buffalo sauce or mix it with a little butter.
- Milk: ½ cup. Milk helps to thin the cheese mixture, making it easier to spread and ensuring a creamy consistency. Use whole milk for a richer flavor, or a lower-fat milk for a lighter option.
- Cheddar Cheese, Shredded: 2 cups. Cheddar cheese adds a sharp, tangy flavor that pairs well with the buffalo and ranch. Use a good quality cheddar for the best results. You can also use a blend of cheddar and Monterey Jack for a milder flavor.
- Mozzarella Cheese, Shredded: 2 cups. Mozzarella cheese adds a gooey, melty texture to the lasagna. Reserve ½ cup for topping to create a golden, bubbly crust.
Optional Toppings:
- Ranch Dressing: For drizzling. Adds extra ranch flavor and a creamy finish. Drizzle it over the lasagna just before serving.
- Green Onions, Chopped: For garnish. Adds a fresh, mild onion flavor and a pop of color. Sprinkle them over the lasagna just before serving.
- Blue Cheese Crumbles: For garnish. Adds a tangy, salty flavor that complements the buffalo and ranch. Sprinkle them over the lasagna just before serving.
Alternative Ingredient Suggestions:
Lasagna:
- Noodle Alternatives: Use gluten-free lasagna noodles for a gluten-free version. You can also use zucchini slices or eggplant slices for a low-carb alternative, but be sure to salt and drain them to remove excess moisture.
- Chicken Alternatives: Use cooked ground chicken or turkey for a different protein option. You can also use cooked shredded pork or beef. Season the ground meat with the ranch seasoning before adding it to the lasagna.
Cheese Mixture:
- Ranch Seasoning Alternatives: Use a homemade ranch seasoning blend or a combination of dried herbs and spices such as dill, parsley, and garlic powder.
- Cream Cheese Alternatives: Use Neufchâtel cheese for a lighter option. You can also use a combination of cream cheese and ricotta cheese for a different texture. Ricotta adds a slightly grainy texture.
- Buffalo Sauce Alternatives: Use a mild or hot sauce of your choice. You can also use a combination of hot sauce and melted butter for a classic buffalo flavor. For a smoky flavor, use chipotle hot sauce.
- Milk Alternatives: Use half-and-half or heavy cream for a richer cheese mixture. You can also use almond milk or soy milk for a dairy-free version.
- Cheddar Cheese Alternatives: Use Monterey Jack, Colby Jack, or pepper jack cheese for different flavor profiles. Monterey Jack adds a mild, creamy flavor, Colby Jack adds a mild, buttery flavor, and pepper jack adds a spicy kick.
- Mozzarella Cheese Alternatives: Use provolone or fontina cheese for a different melty texture. Provolone adds a slightly sharp flavor, and fontina adds a nutty flavor.
Optional Toppings:
- Topping Alternatives: Use chopped cilantro, diced tomatoes, or sliced jalapeños for different garnishes. You can also use crumbled bacon or chopped celery for added texture and flavor.
Step-by-Step Instructions: Creating Your Cheesy Buffalo Ranch Chicken Lasagna Masterpiece
- Prepare the Cheese Mixture: In a large mixing bowl, combine softened cream cheese, ranch seasoning, buffalo sauce, milk, cheddar cheese, and 1 ½ cups of the mozzarella cheese. Mix until smooth and well incorporated. Use a hand mixer or stand mixer for a smoother mixture. Taste the mixture and adjust the seasoning as needed.
- Cook the Lasagna Noodles: Bring a large pot of salted water to a boil. Cook the lasagna noodles according to package instructions until al dente. Drain and lay flat on a clean surface to prevent sticking. If using oven-ready noodles, skip this step.
- Assemble the Lasagna: Spread a thin layer of the cheese mixture on the bottom of a 9×13-inch baking dish. This prevents the noodles from sticking and ensures even cooking. Lay down a layer of lasagna noodles. Spread another layer of the cheese mixture on top of the noodles, followed by a layer of shredded chicken. Repeat the layers, ending with a layer of the cheese mixture on top. Sprinkle the remaining ½ cup of mozzarella cheese evenly over the final layer.
- Bake: Cover the baking dish tightly with aluminum foil and bake in a preheated oven at 375°F (190°C) for 45 minutes. The foil helps to trap moisture and ensures even cooking.
- Uncover and Bake: Remove the foil and bake uncovered for an additional 10 minutes, or until the cheese on top is bubbly and golden. This allows the cheese to brown and the lasagna to set.
- Rest and Serve: Let the lasagna rest for 8–10 minutes before slicing to allow the layers to set. This makes it easier to slice and serve. Garnish with optional toppings such as ranch dressing drizzle, chopped green onions, or blue cheese crumbles.
Beginner Tips and Notes: Mastering the Art of Cheesy Buffalo Ranch Chicken Lasagna
- Soften Cream Cheese: Ensure the cream cheese is fully softened for a smooth mixture.
- Cook Noodles Al Dente: Cook the lasagna noodles al dente to prevent them from becoming mushy.
- Layer Evenly: Layer the ingredients evenly for consistent flavor in each serving.
- Use Rotisserie Chicken: Using rotisserie chicken saves time and adds flavor.
- Adjust Buffalo Sauce: Adjust the amount of buffalo sauce to control the level of spiciness.
- Use Quality Cheese: Use good quality cheese for the best flavor and texture.
Serving Suggestions: Completing Your Cheesy Buffalo Ranch Chicken Lasagna Experience
- Side Salad: Serve with a fresh garden salad or Caesar salad for a light and refreshing side. The crispness of the salad balances the richness of the lasagna.
- Garlic Bread: Pair with warm garlic bread for a comforting and flavorful side. The garlicky flavor complements the buffalo and ranch.
- Vegetable Sides: Serve with roasted vegetables like broccoli, carrots, or asparagus for a healthy side. The roasted vegetables add a touch of sweetness and texture.
- Corn on the Cob: Serve with grilled corn on the cob for a summer-inspired meal. The sweetness of the corn pairs well with the spicy lasagna.
Storage Tips for Leftovers:
- Refrigeration: Store leftover lasagna in an airtight container in the refrigerator for up to 3-4 days.
- Individual Portions: Store leftovers in individual portions for easy reheating and serving. This makes it convenient for quick meals.
- Airtight Containers: Use airtight containers to prevent the lasagna from drying out and absorbing odors from the refrigerator. This helps maintain the flavor and texture.

Conclusion: Share Your Culinary Creations!
This Cheesy Buffalo Ranch Chicken Lasagna is a fantastic way to enjoy a delicious and comforting meal with a unique twist. I encourage you to try this recipe and share your experiences in the comments below! I’d love to hear about your variations, tips, and tricks. Did you experiment with different cheeses, sauces, or toppings? Your feedback is valuable and inspires other home cooks. Let us know how your lasagna turned out and what serving suggestions you enjoyed most. Share your photos and tag me on social media so I can see your lasagna masterpieces! Use #BuffaloRanchLasagna and #EasyLasagnaRecipes so I can find your creations. I also enjoy seeing your cooking adventures on Instagram stories, so feel free to tag me and show off your creations. Happy cooking, and I can’t wait to see what you create!